Research in our group has focused on the effect of nanoscale
structure on 1) biomolecule adsorption, 2) friction and adhesion,
and 3) electrical conductivity of organic molecules. In all
of these cases, we are interested in designing model systems in which the
nanoscale structural and chemical variations can be achieved.
Our group utilizes several high resolution microscopy techniques
to study biological processes at the single molecule level. Currently, we
have ongoing projects studying the conformational dynamics of protein channels
and the submicron structure and dynamics of thin lipid films.
Our research focuses on developing mass spectrometric methods
for analyzing glycoproteins and small organic molecules (like pharmaceuticals
and metabolites). This research has many different potential applications
to human health, from identifying markers for diseases to identifying the
potent form of hormone therapies.
Single-molecule, single-photon methods are currently being
used to examine dynamics and conformations of calmodulin and calmodulin target
recognition and activation. Our study of orientational dynamics is aimed
at understanding the motions of solute molecules in their solvent environment.
The goal of our research program is the development and
application of bioanalytical techniques capable of studying the process of
neuron communication via the release of neurotransmitters at the pre-synaptic
terminal, a process called exocytosis.
The research in our laboratory is focused on understanding
driving forces important in the transport and/or distribution of small molecule
type drugs within the array of intracellular compartments contained within
mammalian cells.
Our primary interests are to detect biomarkers of DNA damage in living systems using microdialysis and to enhance separation and detection limits of biological samples in electrophoretic separations. Separation methods employed include liquid chromatography and capillary electrophoresis, with ultraviolet, electrochemical, and mass spectrometric detection.
Our research group is focused on the development of sensitive and selective analytical methods for the detection of peptides, amino acids, neurotransmitters, and drugs in biological fluids.
The Plasma Research Laboratory is currently collaborating with engineers in industry and government laboratories who have provided us with materials and additional testing capabilities. Our current research deals with the development of etch processes for wide bandgap semiconductors such as SiC, GaN, and ZnO.
The main emphasis of our program is the elucidation of structure-function
relationships in heme containing proteins.
Professor Schöneich's research focuses on the oxidative post-translational modification of proteins in vitro and in vivo.
Professor Stobaugh's research emphasizes liquid phase capillary column separation techniques (capillary electrochromatography, capillary liquid chromatography and capillary electrophoresis) and various chemistries for the enhancement of separation and detection.
Research Interests: Analytical Chemistry: redox biochemistry,
in-vivo measurements with biosensors, analysis of chromosome structure, development
of analytical reagents based on biological recognition.
